01 · mechanism of action
Semax was originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and has been studied in numerous animal experiments. In rat models semax produced a significant increase of BDNF (Brain-Derived Neurotrophic Factor) in the hippocampus — a central factor in learning and memory consolidation. In stroke models it reduced neuronal cell loss in ischemic regions by up to 40 % and significantly improved motor recovery. Behavioral studies showed measurable improvements in maze-test memory performance and reduction of oxidative stress in brain tissue. The substance modulates dopaminergic and serotonergic systems, leading to reduced anxiety and improved cognitive flexibility in behavioral tests.