mots-c

mitochondrial-derived peptide · ampk activator

First peptide ever shown to be encoded directly by mitochondrial DNA (USC, 2015). Reverses age-related metabolic decline in animal models.

vial size

for laboratory use only — not for human consumption. ships from tallinn within 24 h, EU delivery in 48 h.

research monograph

what the literature shows.

A condensed monograph drawn from preclinical and clinical literature. Cited mechanisms, specifications and the research case for mots-c.

01 · mechanism of action

MOTS-c is a mitochondrially-encoded peptide discovered in 2015 by the Chang Lee group at USC — a groundbreaking find as it is the first known peptide transcribed directly from mitochondrial DNA. In animal studies on mice MOTS-c normalized age-related weight gain and insulin resistance: treated aged mice showed no increase in visceral fat despite normal nutrition. Mechanistically MOTS-c activates the AMPK signaling pathway and regulates the folate-methionine cycle, shifting metabolism toward fat burning. In endurance tests MOTS-c-treated mice ran significantly longer than controls. MOTS-c levels naturally decline with age, and supplementation in aged animals restored metabolic parameters to young-animal levels.

02 · product specifications

Each vial contains 10 mg MOTS-c as lyophilized powder at ≥ 99.0 % purity (HPLC). Suitable for biochemical studies on mitochondrial signaling, metabolic assays and investigations of metabolic homeostasis in cell culture systems.

03 · research advantages

As a mitochondrially-encoded peptide MOTS-c is a completely novel research subject with unique biological relevance. The documented effects on age-related metabolism, insulin sensitivity and physical performance in animal studies make it a key molecule of modern longevity research.

datasheet

full specification.

Identity, mass, purity reference and storage profile for the current lot of mots-c. For laboratory use only.

catalog no.: PH-6003-M
cas: 1627580-64-6
molecular weight: 2174.6 g/mol
purity (hplc): ≥ 99.0 % (hplc)
endotoxin: < 0.5 eu/mg
sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
residues: 16 aa
appearance: white lyophilized powder
reconstitution: bacteriostatic water · 0.9 % nacl
stability (reconstituted): 21 d at 2–8 °c
shelf life (lyophilized): 24 m at −20 °c
storage: −20 °c, protect from light
current lot: mts-260306
current exp.: 09 / 2027
lead time: ships in 24 h

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